|
Symbol Name ID |
Mpz
myelin protein zero MGI:103177 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Tongue fasciculations |
Increased CSF protein concentration |
Dysphagia |
Decreased number of peripheral myelinated nerve fibers |
Onion bulb formation |
Peripheral demyelination |
Segmental peripheral demyelination/remyelination |
Peripheral dysmyelination |
Myelin outfoldings |
Myelin tomacula |
Hypertrophic nerve changes |
Axonal degeneration/regeneration |
Peripheral axonal neuropathy |
Decreased motor nerve conduction velocity |
Decreased sensory nerve conduction velocity |
Decreased nerve conduction velocity |
Areflexia |
Hyporeflexia |
Broad-based gait |
Steppage gait |
Motor delay |
Peripheral neuropathy |
Somatic sensory dysfunction |
Distal sensory impairment |
Impaired distal vibration sensation |
Sensory ataxia |
| Disease(s) Associated with MPZ | ||||||||||||||||||||||||||
| Charcot-Marie-Tooth disease dominant intermediate D | ||||||||||||||||||||||||||
| Charcot-Marie-Tooth disease type 1B | ||||||||||||||||||||||||||
| Charcot-Marie-Tooth disease type 2I | ||||||||||||||||||||||||||
| Charcot-Marie-Tooth disease type 2J | ||||||||||||||||||||||||||
| Charcot-Marie-Tooth disease type 3 |
| Mouse Phenotypes | nervous system phenotype |
increased Schwann cell proliferation |
abnormal Schwann cell morphology |
increased Schwann cell number |
abnormal nervous system development |
abnormal axon radial sorting |
abnormal neuron morphology |
abnormal myelin sheath morphology |
decreased myelin sheath thickness |
tomacula |
neuron degeneration |
abnormal sciatic nerve morphology |
axon degeneration |
abnormal nervous system physiology |
abnormal myelination |
demyelination |
dysmyelination |
abnormal action potential |
abnormal nerve conduction |
decreased nerve conduction velocity |
decreased prepulse inhibition |
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| Availability | Mouse Genotype | |||||||||||||||||||||
| Mpzem1(IMPC)Tcp/Mpzem1(IMPC)Tcp | ||||||||||||||||||||||
| Mpztm1.1Wra/Mpztm1.1Wra | ||||||||||||||||||||||
| Mpztm1Msch/Mpztm1Msch Tg(Mpz)80.4Wra/0 |
* | |||||||||||||||||||||
| Mpztm1Msch/Mpztm1Msch | ||||||||||||||||||||||
| Mpztm1Msch/Mpztm1Msch Tg(Mpz*S63X)31Mes/0 |
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| Mpztm1Msch/Mpztm1Msch Tg(Mpz*S63C)33Mes/0 |
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| Mpztm1Msch/Mpztm1Msch Tg(Mpz)88.4Mfel/0 |
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| Mpztm3.1Wra/Mpztm3.1Wra | ||||||||||||||||||||||
| Mpzttrr/Mpzttrr | ||||||||||||||||||||||
| Tg(Mpz)80.3Wra/Tg(Mpz)80.3Wra | ||||||||||||||||||||||
| Mpztm1.1Wra/Mpz+ | ||||||||||||||||||||||
| Mpztm1Msch/Mpz+ | ||||||||||||||||||||||
| Mpztm1Msch/Mpz+ Tg(Mpz*S63X)31Mes/0 |
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| Mpztm1Msch/Mpz+ Tg(Mpz*S63C)33Mes/0 |
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| Mpztm1Msch/Mpz+ Tg(Mpz)88.1Mfel/0 |
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| Mpztm1Msch/Mpz+ Tg(Mpz)88.4Mfel/0 |
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| Mpztm3.1Wra/Mpz+ | ||||||||||||||||||||||
| Tg(Mpz)80.2Wra/0 | ||||||||||||||||||||||
| Tg(Mpz)80.3Wra/0 | ||||||||||||||||||||||
| Tg(Mpz)80.4Wra/0 | ||||||||||||||||||||||
| Tg(Mpz)88.1Mfel/0 | ||||||||||||||||||||||
| Tg(Mpz)88.2Mfel/0 | ||||||||||||||||||||||
| Tg(Mpz)88.4Mfel/0 | ||||||||||||||||||||||
| Tg(Mpz*S63C)32Mes/0 | ||||||||||||||||||||||
| Tg(Mpz*S63C)33Mes/0 | ||||||||||||||||||||||
| Tg(Mpz*S63X)30Mes/0 | ||||||||||||||||||||||
| Tg(Mpz*S63X)31Mes/0 | ||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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